Absolute Configuration of L-Methionine Sulfoximine as a Toxic Principle in Cnestis palala (LOUR.) MERR.
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概要
- 論文の詳細を見る
An unusual amino acid, L-methionine sulfoximine (1), has been isolated from the fresh seeds of Cnestis palala (LOUR.) MERR. [Connaraceae]. The absolute configuration of the natural sulfoximine (1) was confirmed to be 2(S)-methionine S(S)-sulfoximine [(2S, SS)-2-amino-4-(S-methylsulfonimidoyl)-n-butanoic acid] by comparison of the [α]_D value and IR spectrum with those of authentic samples obtained through the optical resolution of synthetic materials. Acute toxicity of the seeds of C. palala in a beagle dog was also studied.
- 社団法人日本薬学会の論文
- 1993-02-15
著者
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関根 利一
千葉大学薬学部医薬品素材学講座
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池上 文雄
Faculty of Pharmaceutical Sciences, Chiba Unievrsity
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村越 勇
Faculty of Pharmaceutical Sciences, Chiba Unievrsity
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関根 利一
Faculty of Pharmaceutical Sciences, Chiba University
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藤井 祐一
(株)ツムラ
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藤井 祐一
Tsumura Research Institute of Pharmacology
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前嶋 清美
Faculty of Pharmaceutical Sciences, Chiba University
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吉永 幸一郎
Tsumura Research Institute for Pharmacology
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OKONOGI Siriporn
Pharmacy, Chiang Mai University
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村越 勇
千葉大
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池上 文雄
Faculty Of Pharmaceutical Sciences Chiba University
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池上 文雄
薬用植物学
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Okonogi Siriporn
Pharmacy Chiang Mai University
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前嶋 清美
Faculty Of Pharmaceutical Sciences Chiba University
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