Biomimetic Synthesis of Heterocyclic β-Substitutd Alanines by Pyridoxal 5'-Phosphate-Catalyzed Chemical Reactions

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概要

• 論文の詳細を見る

• Several heterocyclic β-substituted alanines were biomimetically synthesized by incubating 0.1 M acetate buffer solution containing the appropriate heterocyclic compound and O-acetylserine or serine in the presence of pyridoxal 5'-phosphate (PLP) and metal ions. This PLP-catalyzed chemical reaction depends upon pH, metal ions and temperature. The addition of Ga^<3+>, Fe^<3+> or Al^<3+> enhanced the rate of synthesis. The optimum of the various reaction conditions of this biomimetic method is described.

• 公益社団法人日本薬学会の論文
• 1986-04-25

著者

• 池上 文雄

  Faculty of Pharmaceutical Sciences, Chiba Unievrsity

• 村越 勇

  Faculty of Pharmaceutical Sciences, Chiba Unievrsity

• 村越 勇

  千葉大

• 池上 文雄

  Faculty Of Pharmaceutical Sciences Chiba University

• 米田 宜弘

  Faculty of Pharmaceutical Sciences, Chiba University

• 井原 はるみ

  Faculty of Pharmaceutical Sciences, Chiba University

• 坂上 久美子

  Faculty of Pharmaceutical Sciences, Chiba University

• 小出 千春

  Faculty of Pharmaceutical Sciences, Chiba University

• 米田 宜弘

  Faculty Of Pharmaceutical Sciences Chiba University

• 坂上 久美子

  Faculty Of Pharmaceutical Sciences Chiba University

• Ikegami Fumio

  Research Center Of Medicinal Resources Faculty Of Pharmaceutical Sciences Chiba University

• 小出 千春

  Faculty Of Pharmaceutical Sciences Chiba University

• 井原 はるみ

  Faculty Of Pharmaceutical Sciences Chiba University

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