Interaction of Some Plant Heterocyclic β-Substituted Alanines with Rat Brain N-Methyl-D-aspartate (NMDA) Receptors
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概要
- 論文の詳細を見る
The neuropharmacological actions of some plant heterocyclic β-substituted alanines on rat brain N-methyl-D-aspartate (NMDA) receptors were studied. Of the compounds tested, 3-N-oxalyl-L-2,3-diaminopropanopic acid (β-ODAP), the causal agent of human neurolathyrism, exhibited an inhibitory activity on the NMDA receptor binding assay at a relatively high concentration (IC_<50> : 4.7×10^<-5>M). The biochemical precursor of β-ODAP, β-(isoxazolin-5-on-2-yl)-L-alanine (BIA) was inactive in this assay. These results suggest that β-ODAP, the neurotoxin of Lathyrus sativus, in addition to its excitatory action on α-amino-3-hydroxy-5-methylisoxazole-4-propanoic acid (AMPA) receptors, also has neurotoxic potential through its action on NMDA receptors.
- 公益社団法人日本薬学会の論文
- 1995-02-15
著者
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池上 文雄
Faculty of Pharmaceutical Sciences, Chiba Unievrsity
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LAMBEIN Fernand
Laboratory of Physiological Chemistry, Faculty of Medicine, State University of Ghent
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村越 勇
Faculty of Pharmaceutical Sciences, Chiba Unievrsity
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村越 勇
千葉大
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草間(江口) 國子
College Of Pharmacy Nihon University
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Kusama-eguchi Kuniko
College Of Pharmacy Nihon University
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池上 文雄
Faculty Of Pharmaceutical Sciences Chiba University
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杉山 栄美
College of Pharmacy, Nihon University
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渡邊 和子
College of Pharmacy, Nihon University
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Lambein Fernand
Laboratory Of Physiological Chemistry Faculty Of Medicine State University Of Ghent
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杉山 栄美
College Of Pharmacy Nihon University
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渡邊 和子
日本大学薬学部生物学研究室
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Ikegami Fumio
Research Center Of Medicinal Resources Faculty Of Pharmaceutical Sciences Chiba University
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Watanabe Kazuko
College Of Pharmacy Nihon University
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