Accelerating Effect of Glutathione on Hydroxylation of Phenylalanine by Stimulated Polymorphonuclear Leukocytes
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概要
- 論文の詳細を見る
Sulfhydryl compounds significantly accelerated the hydroxylation of phenylalanine by stimulated polymorphounclear leukocytes. The reduced form of glutathione (G-SH) was most effective. The hydroxylation reaction in the presence of G-SH was largely prevented by superoxide dismutase and hydroxyl radical scavengers. The results suggest that a much faster production of hydroxyl radical may occur in a reaction mixture containing both G-SH and stimulated polymorphonuclear leukocytes than in that containing stimulated polymorphonuclear leukocytes alone.
- 社団法人日本薬学会の論文
- 1990-06-25
著者
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早川 堯夫
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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石光 進
Kyoto Phramaceutical Univeristy
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小原 晃
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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藤本 貞毅
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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石光 進
Laboratory of Biochemistry, Kyoto Pharmaceutical University
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金沢 治男
Laboratory of Biochemistry, Kyoto Pharmaceutical University
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Ohara A
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Chara A
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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早川 堯夫
Division Of Biological Chemistry National Institute Of Hygienic Sciences
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金沢 治男
Kyoto Pharmaceutical University
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