Nonenzymatic Hydroxylation of Phenylalanine by Ascorbic Acid and Cu^<++>
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概要
- 論文の詳細を見る
When phenylalanine was treated with ascorbic acid and Cu^<++> in acetate buffer (pH 6.0), the decomposition of phenylalanine was observed. Cu^<++> accelerated remarkably the decomposition of phenylalanine as compared with other transition metal ions. In contrast, nitrogen gas, other reducing agents and radical scavengers prevented the decomposition. The results indicate that a transient free radical intermediate, formed during the autoxidation of ascorbic acid, is responsible for the decomposition. The ascorbic acid-Cu^<++> system was found to decompose phenylalanine giving hydroxy-phenylalanines such as dihydroxyphenylalanine, m-tyrosine, p-tyrosine and o-tyrosine.
- 公益社団法人日本薬学会の論文
- 1977-03-25
著者
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石光 進
Kyoto Phramaceutical Univeristy
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小原 晃
Kyoto College of Pharmacy
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小原 晃
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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藤本 貞毅
Kyoto Pharmaceutical University
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藤本 貞毅
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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