Hydroxylation of Phenylalanine by Myeloperoxidase-Hydrogen Peroxide System
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概要
- 論文の詳細を見る
When phenylalanine was incubated with myeloperoxidase (MPO) and hydrogen peroxide (H_2O_2), p-tyrosine, m-tyrosine and o-tyrosine were identified as hydroxylated products. With inactivated MPO, no significant amount of tyrosines was formed. Tyrosine formation was dependent on reaction time and the MPO concentration. The addition of Cl^- at lower concentration to the MPO-H_2O_2 system resulted in increase of tyrosine formation, though Cl^- at higher concentration reduced the formation. The tyrosine formation by both MPO-H_2O_2 and MPO-H_2O_2-Cl^- systems was significantly prevented by hydroxy radical scavengers such as mannitol, benzoate and foormate. Superoxide dismutase was also an effective inhibitor of tyrosine formation from phenylalanine by MPO-H_2O_2 system.
- 社団法人日本薬学会の論文
- 1991-06-25
著者
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石光 進
Kyoto Phramaceutical Univeristy
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小原 晃
Kyoto College of Pharmacy
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小原 晃
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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藤本 貞毅
Kyoto Pharmaceutical University
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藤本 貞毅
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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河上 奈保子
Kyoto Pharmaceutical University
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平山 悟
Kyoto Phramaceutical Univeristy
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Ohara A
Kyoto Pharmaceutical Univ. Kyoto Jpn
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河上 奈保子
京都薬大 衛生化学
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Chara A
Laboratory Of Biochemistry Kyoto Pharmaceutical University
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Kawakami Naomi
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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