1,2-テトラメチレン-3,4-ジヒドロ-β-カルボリンの合成
スポンサーリンク
概要
- 論文の詳細を見る
3,4-Dihydro-1,2-tetramethylene-β-carboline (I) was synthesized from 2-(2'-pyridyl) indole by a new method.The latter, when treated with fromaldehyde and diethylamine, readily geve the β-diethylaminomethyl derivative (III) in a fair yield. Its methiodide (V), made advantageously via the corresponding methosulfate (IV), was reacted with aqueous alkali cyanide to give the indolylacetonitrile (VI), which was hydrolysed and esterified, giving the indolylacetic ester (VIII). LiAlH_4-reduction of this ester yielded the β-hydroxyethyl derivative (IX), which gave directly the β-carbolinium bromide (X) by the agency of PBr_3,catalytic reduction of which gave (I) in a smooth reaction. The hitherto unknown 2-(3'-pyridyl)-and 2-(4'-pyridyl)-indoles, their metho-salts and the corresponding 2-piperidyl indoles were also prepared.
- 公益社団法人日本薬学会の論文
- 1956-02-20
著者
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菅沢 重彦
Pharmaceutical Institute Medical Faculty University of Tokyo
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金岡 祐一
Pharmaceutical Sciences, Hokkaido University
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金岡 祐一
Toyama Women's College
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金岡 祐一
Pharmaceutical Institute Medical Faculty University Of Tokyo
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寺島 正直
Pharmaceutical Institute, Medical Faculty, University of Tokyo
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寺島 正直
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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寺島 正直
Pharmaceutical Institute Medical Faculty University Of Tokyo
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