Syntheses of HIV-Protease Inhibitors Having a Peptide Moiety Which Binds to GP120
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概要
- 論文の詳細を見る
Some HIV-protease inhibitor derivatives having an N-carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta-positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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Achiwa Kazuo
School Of Pharmaceutical Sciences University Of Shizuoka
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Uchiyama Taketo
School Of Pharmaceutical Sciences University Of Shizuoka
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ASAGARASU Akira
School of Pharmaceutical Sciences, University of Shizuoka
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Asagarasu A
School Of Pharmaceutical Sciences University Of Shizuoka
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Asagarasu Akira
School Of Pharmaceutical Sciences University Of Shizuoka
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