Synthesis of New Atropisomeric Bisphosphine Ligands Bearing Chiral Phospholane and Their Use in Asymmetric Hydrogenation
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概要
- 論文の詳細を見る
Novel chiral bisphosphine ligands bearing (2S, 5S)-dimethylphospholano group on a chiral biphenyl back-bone were designed and prepared. Asymmetric hydrogenations of a ketone and an olefin with the rhodium(I) complex catalysts prepared in situ from [Rh(COD)Cl]_2 and (R)-2,2'-bis[(2"S, 5"S)-2", 5"-dimethylphospholano]-5,5'-dimethoxy-4,4', 6,6'-tetramethyl-1,1'-biphenyl and (S)-2,2'-bis[(2"S, 5S")-2", 5"-dimethylphospholano]-5,5'-dimethoxy-4,4', 6,6'-tetramethyl-1,1'-biphenyl gave the corresponding alcohol and alkane in high yields. The asymmetric hydrogenations with these ligands showed a different enantioselectivity.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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ACHIWA Kazuo
School of Pharmaceutical Sciences, University of Shizuoka
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Achiwa Kazuo
School Of Pharmaceutical Sciences University Of Shizuoka
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FUJIE Naoto
School of Pharmaceutical Sciences, University of Shizuoka
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MATSUI Mariko
School of Pharmaceutical Sciences, University of Shizuoka
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Fujie N
School Of Pharmaceutical Sciences University Of Shizuoka
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Matsui Mariko
School Of Pharmaceutical Sciences University Of Shizuoka
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Fujii Naoto
School of Pharmaceutical Sciences, University of Shizuoka
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