Design and Synthesis of Haptens for Application to the Preparation of Chiral 1,4-Dihydropyridines
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概要
- 論文の詳細を見る
Lipase-catalyzed enzymatic hydrolysis of dimethyl esters of 1,4-dihydropyridines to the monoester, which is an important intermediate for the synthesis of optically active 1,4-dihydropyridines, does not proceed directly. This paper describes the design and synthesis of novel haptens having a phosphonate group containing the requisite oxyanionic character to mimic the tetrahedral intermediate of hydrolysis, and the application of these compounds for generating antibodies with catalytic ability for the enantioselective partial hydrolysis of the dicarboxylic dimethyl ester (1) of a 1,4-dihydropyridine derivative to generate the monocarboxylic acid (2).
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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IKEDA Kiyoshi
School of Pharmaceutical Sciences, University of Shizuoka
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Achiwa Kazuo
School Of Pharmaceutical Sciences University Of Shizuoka
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Kato Tatsuhisa
School Of Pharmaceutical Sciences University Of Shizuoka
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Suzuki Takehisa
School Of Pharmaceutical Sciences University Of Shizuoka
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Ikeda Kiyoshi
School Of Information Science Japan Advanced Institute Of Science And
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