糖尿病性腎症に対するLDLアフェレシス

概要

論文の詳細を見る
Factors other thall hyperglycemia have been suggested to contribute to the progression of overt diabetic nephropathy (DN) with massive proteinuria, and hyperlipidemia has recently been incriminated in this process. Expecting the effect of lipid lowering in the retardation of progression of DN, we applied LDL apheresis a total of 6 times, twice a week for 3 weeks, to nine patients whose renal function had been progressively declining. In seven patients, renal function was improved only transiently during the period of therapy and 2 weeks after therapy. Two patients who received additonal LDL apheresis, once every 2 weeks repeatedly showed the suppression of decline in renal function for 5 to 9 months. In conclusion, LDL apheresis may retard the progression of overt DN when it is performed repeatedly for a long period at two-week intervals.
日本アフェレシス学会の論文
1998-05-31