Uric acid concentrations in the kidney and aorta in experimental hyperuricemic rats

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To elucidate conditions of gout, thirty Wistar strain hyperuricemic rats were fed a commercially available chow containing 2% oxonic acid and 3% uric acid. Uric acid concentrations were measured in the kidney and abdominal aorta after two and four fed weeks. The uric acid concentrations in the renal cortex, outer medulla, inner medulla and papillarly tips were significantly increased compared with control rats, and this tendency was greater in the medulla than cortex. Uric acid concentrations in the kidney were higher after four weeks rats than after two weeks. The uric acid concentrations in aorta were also increased in hyperuricemic rats as compared with control. rats, however, the values were lower than those in the inner medulla and papillary tips. A positive correlation was found between the value of uric acid concentrations in the kidney tissues and urinary excretion of uric acid, and serum uric acid levels. This correlation was more significant in the inner medulla and papillary tips. The same correlation was also noticed between the level of uric acid concentration in aorta and serum uric acid. Our findings suggest that persistent manifestation of hyperuricemia and hyperuricosuria causes the deposition of uric acid and urate in various internal organs.
Japanese Society of Gout and Nucleic Acid Metabolismの論文