ラットの飼料タンパク質の利用に及ぼすビタミンB_<12>欠乏の影響

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Protein nutrition in vitamin B_<12> (B_<12>)-deficient rats was evaluated not only by examining the effect of dietary protein on B_<12>-deficiency but also by examining the utilization of dietary protein in B_<12>-deficient rats. Severe B_<12>-deficiency was confirmed in rats fed on a soybean protein diet by a remarkable increase in urinary methylmalonic acid (MMA) and a striking depression of hepatic B_<12>-dependent enzymes. Growth retardation and an increase in urinary excretion of MMA were prominent in the B_<12>-deficient rats fed on a high protein diet, and the amount of MMA excretion was proportionally increased to the amount of dietary protein. Therefore, it was obvious that the high protein diet caused severe and rapid B_<12>-deficiency. The severe B_<12>-deficient rats showed growth retardation even in pair-feeding. Plasma proteins significantly decreased in B_<12>-deficient rats than those in pair-feeding control rats , and the excretion of urinary nitrogen compounds was also significantly decreased. The activity of hepatic cystathionine β-synthase and hepatic S-adenosylmethionine content decreased in severe B_<12>-deficient rats which showed a distinct depression of hepatic methionine synthase activity, and these decreases could be alleviated partially by methionine supplementation. It was assumed that methionine resynthesis, availability and dietary protein utilization were depressed in severe B_<12>-deficient rats.
日本ビタミン学会の論文
1997-03-25

ラットの飼料タンパク質の利用に及ぼすビタミンB_<12>欠乏の影響

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