Data Base Simulation of Batch and Fed-Batch Cultures for α-Amylase Production Using a Culture Data Base and a Statistical Procedure
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概要
- 論文の詳細を見る
A practical simulation method using a culture data base and a statistical procedure was developed. This Data Base Simulation (DBS) method enables various time courses of batch and fed-batch cultures to be simulated by using multiple regression models in combination with a culture data base. The culture data base contained culture data and specific rates (μ, etc.), which were smoothed and estimated using a cubic spline function based on raw data gained under various experimental conditions. The cubic spline function was effective in improving data smoothing, data interpolation and the estimation of specific rates from raw culture data. The coefficients of the regression models were estimated by regression analysis using data sets statistically selected from the data base, followed by numerical calculation of the time courses of state variables over specified intervals. Then the coefficients were renewed and the simulation ws continued to the end of the cultivation by repeating the coefficient renewals. The method was tested using experimental data from batch and fed-batch cultures for α-amylase production by Bacillus amyloliquefaciens. The culture data base was successfully produced by applying a cubic spline function to more than 30 pieces of experimental data. The simulated results showed that the method was able to appropriately predict the time-courses of non-linear batch and fed-batch cultures for a wide range of culture conditions without using specific deterministic models.
- 社団法人日本生物工学会の論文
- 1993-10-25
著者
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Kishimoto Michimasa
Department of Chemistry and Materials Technology, Kyoto Institute of Technology
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Kishimoto Michimasa
Department Of Biological Science Technology Scientific University Of Tokyo
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Kishimoto Mishimasa
Department Of Biological Science And Technology Science University Of Tokyo
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Kishimoto Michimasa
Department Of Biotechnology Faculty Of Engineering Osaka University
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Kishimoto Michimasa
Deparmtnet Of Biotechnology Osaka University
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HORIUCHI JUN-ICHI
Biotechnology Research Department, Research Center, Toyo Engineering Corporation
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KAMASAWA MASAMI
Biotechnology Research Department, Research Center, Toyo Engineering Corporation
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MIYAKAWA HISASHI
Biotechnology, Research Department, Research Center, Toyo Engineering Corporation
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MOMOSE HARUO
Department of Biological Science and Technology, Science University of Tokyo
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Horiuchi Jun-ichi
Biotechnology Research Department Research Center Toyo Engineering Corporation
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Momose H
Sci. Univ. Tokyo Chiba
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Momose Haruo
Department Of Biological Science And Technology Tokyo University Of Science
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Momose Haruo
Department Of Biological Science And Technology Science University Of Tokyo
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Kishimoto Michimasa
International Center Of Cooperative Research In Biotechnology Japan Osaka University
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Horiuchi J
Kitami Inst. Technol. Hokkaido
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Kamasawa Masami
Biotechnology Research Department Research Center Toyo Engineering Corporation
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Miyakawa H
Sasebo Coll. Technology Nagasaki Jpn
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MIYAKAWA HISASHI
Biotechnology Research Department, Research Center, Toyo Engineering Corporation
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