Relative Biological Effectiveness of Accelerated Heavy Ions for Induction of Morphological Transformation in Syrian Hamster Embryo Cells

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概要

• 論文の詳細を見る

• Syrian hamster embryo cells were used to study the morphological transformation induced by accelerated heavy ions with different linear energy transfer (LET) ranging from 13 to 400 keV/μm. Exponentially growing cells were irradiated with ^<12>C or ^<28>Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), then inoculated to culture dishes. Morphologically altered colonies were scored as transformants. Over the LET range examined, the frequency of transformation induced by the heavy ions increased sharply at very low doses no greater than 5 cGy. The relative biological effectiveness (RBE) of the heavy ions relative to X-rays first increased with LET, reached a maximum value of about 7 at 100 keV/μm, then decreased with the further increase of LET. Our findings confirmed that high LET heavy ions are much more effective than X-rays for the induction of in vitro cell transformation.

• 日本放射線影響学会の論文

著者

• Suzuki Minoru

  Particle Radiation Oncology Research Center Kyoto University

• Suzuki M

  Particle Radiation Oncology Research Center Kyoto University

• Suzuki Fumio

  Fukujuji Hospital

• Suzuki Fumio

  関西外国語大学

• Suzuki Fumio

  First Department of Internal Medicine

• FURUSAWA Yoshiya

  Space and Prticle Radiation Science Research Group, national Institute of Radiological Science (NIRS

• KATO Tomohisa

  Radiat Biol Center, Kyoto Univ

• Kato Takesi

  School Of Medicine Osaka University

• Kato Tomohisa

  関西外国語大学

• Kato Tomohisa

  Radiation Biology Center Kyoto University

• Kato Tomohisa

  Radiat Biol Center Kyoto Univ

• SUZUKI MASAO

  Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences

• Han Zhen-bo

  関西外国語大学

• Han Zhen-bo

  Radiation Biology Center Kyoto University

• IKENAGA MITUO

  Radiation Biology Center, Kyoto University

• SUZUKI FUMIO

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• SUZUKI HIROMI

  Radiation Biology Center, Kyoto University

• Suzuki Masao

  Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences

• Kato T

  Radiation Biology Center Kyoto University

• Kato Tomohisa

  Radiat. Biol. Center Kyoto University

• Ikenaga M

  Radiation Biology Center Kyoto University

• Ikenaga Mituo

  関西外国語大学

• Suzuki Fumio

  Mitsubishi Electric Corporation

• Suzuki Fumio

  Research Institute For Radiation Biology And Medicine Hiroshima University

• Suzuki Fumio

  Department Of Regulatory Radiobiology Research Institute For Radiation Biology And Medicine Hiroshim

• Furusawa Y

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Ikenaga Mituo

  Radiat. Biol. Cent. Kyoto Univ.

• Suzuki H

  Tohoku Univ. Miyagi Jpn

• Suzuki Hiroyuki

  Neutron Device Engineering Department Of Quantum Science And Energy Engineering Tohoku University

• Suzuki Fumio

  Division Of Cardiology Kawaguchi Kohgyo General Hospital

• Furusawa Yoshiya

  Space And Particle Radiation Science Res. Group Nirs.

• Suzuki Fumio

  Tokyo Med. And Dental Univ.

• Han Zhenbo

  Radiat. Biol. Center Kyoto Univ.

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