Enzymatic Repair Mechanisms for Base Modifications Induced by Oxygen Radicals

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概要

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• 1. DNA damage produced by oxygen radicals. Oxygen radicals are produced by cellular metabolism, ionizing radiation, and environmental mutagens. These radicals react with DNA yielding lesions such as base modifications, strand breaks and crosslinks. Of these, base modifications are primary causes of oxygen radical-induced cell lethality, mutagenesis, carcinogenesis, aging and a number of diseases. Purine modifications include 4, 6-diamino-5-formamidopyrimidine (Fapy-A), 2, 6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy-G), 8-hydroxyguanine (8ohG) and 8-hydroxyadenine (8ohA). Base pairing between 8ohG and dAMP leads to G:C to T:A transversion mutations. Pyrimidine modifications caused by oxygen radicals include thymine glycols, 5-hydroxycytosine and 5-hydroxyuracil. These base modifications and the amounts formed after 420 Gy of γ-rays are shown in Table 1.

• 日本放射線影響学会の論文

著者

• YAMAMOTO KAZUO

  Biological Institute, Graduate School of Science, Tohoku University

• YONEI Shuji

  Laboratory of Radiation Biology, Graduate School of Science, Kyoto University

• YONEI Shuji

  Radiat. Biol. Grad. Sch. Sci. Kyoto Univ.

• YANO Sachiko

  Japan Aerospace Exploration Agency

• YONEI Shuji

  Department of Biological Sciences, Graduate School of Science, Kyoto University

• Yamamoto Kazuo

  東北大学 生命科学研究科

• Yamamoto K

  Department Of Molecular Pathology Cancer Research Institute Kanazawa University

• URAKI FUMIKO

  Biological Institute, Graduate School of Science, Tohoku University

• YUKAWA OSAMI

  Division of Biology and Oncology, National Institute of Radiological Science

• Uraki Fumiko

  Biological Institute Graduate School Of Science Tohoku University

• Yonei Shuji

  Labo. Radiat. Biol. Grad. Sch. Sci. Kyoto Univ.

• Yonei Shuji

  Laboratory Of Radiation Biology Graduate School Of Science Kyoto University

• Yukawa O

  National Inst. Radiological Sci. Chiba Jpn

• Yukawa Osami

  Division Of Biology And Oncology National Institute Of Radiological Sciences

• Yonei Shuji

  Department Of Biological Sciences Graduate School Of Science Kyoto University

• Yonei Shuji

  Lab. Radiat. Biol. Grad. Sch. Sci. Kyoto Univ.

• Yonekura Shin-ichiro

  Radiat. Biol. Grad. Sch. Sci. Kyoto Univ.

• Yonei Shuji

  Lab. Of Radiat. Biol. Graduate School Of Science.

• Yonei Shuji

  Kyoto Univ. Kyoto Jpn

• Yonekura Shin-ichiro

  Department Of Biological Sciences Graduate School Of Science Kyoto University

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