HETERO-TRANSPLANTATION OF HUMAN ENDOMETRIAL CARCINOMA INTO NUDE MOUSE EFFECTS OF SEX STEROID HORMONES ON MORPHOLOGICAL ASPECTS OF UNDIFFERENTIATED ADENOCARCINOMA CELLS
スポンサーリンク
概要
- 論文の詳細を見る
7例のヒト子宮内膜癌を雌nude mouseに移植した結果,未分化型の2例のみが初代移植に成功し,他の分化型,中等度分化型,及び腺棘型は不成功であった.初代移植に成功した2例のうち,1例(JEA-1)が継代移植に成功し,現在14代目を数え,その移植率は100%である.以上より,子宮内膜癌においても,従来の報告の如く,組織分化度の低いものほど移植率が高い結果を得た.JEA-1の原腫瘍組織はまったく腺腔構造の認められない小型未分化細胞で構成され,極く一部に扁平上皮化生を思わせる部分が存在した.また,原腫瘍組織中のestrogen及びprogesterone receptorは蔗糖密度勾配法で測定限界以下(-)であつた.継代移植された腫瘍組織は形態的にも,receptorレベルにおいても変化を示さず,それ故,JEA-1を用いてsex steroid hormone感受性の予備実験を行った.estrogen投与では電顕的に子宮内膜増殖期様変化,estrogen-progesterone併用投与では分泌期様変化を認めた.また,estrogen投与では,dextran coated charcoal法でわずかながらestrogen receptorの存在が認められた.このことから,estrogen receptor(-)の子宮内膜癌において,適量のestrogen投与によるestrogen及びprogesterone receptor誘発の可能性が示唆された.
- 社団法人日本産科婦人科学会の論文
- 1980-10-01
著者
-
OHKAWA Kiyoshi
Department of Biochemistry [I], Jikei University School of Medicine
-
Ohkawa Kiyoshi
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
OCHIAI Kazunori
Department of Obstetrics and Gynecology, Jikei University School of Medicine
-
KATO Junzo
Department of Obstetrics and Gynecology, Yamanashi Medical University
-
TOHTAKE Takayasu
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
TERASHIMA Yoshiteru
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
Fukushima Kazuo
Department of Microbiology, Nihon University School of Dentistry at Matsudo
-
Ohkawa Kiyoshi
Department Of Biochemistry 1 Jikei University School Of Medcine
-
KOIKE Kiyohiko
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
AMASAKI Hirofumi
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
SASAKI Hideaki
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
KUJI Naoshi
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
Kato Junzo
Department Of Obstetrics And Gynecology Yamanashi Medical College
-
Kuji Naoshi
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Koike Kiyohiko
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Fukushima Kazuo
Department Of Environmental Sciences Faculty Of Science Shinshu University
-
Terashima Yoshiteru
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Ochiai Kazunori
Department Of Obstetrics And Gynecology Department Of Clinical Oncology The Jikei University School
-
Ochiai Kazunori
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Tohtake Takayasu
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Amasaki Hirofumi
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Kato Junzo
Department Of Obstetrics And Gynecology Teikyo University School Of Medictine
-
Kato Junzo
Department Of Obstetrics And Gyleecology Yamanashi Medical University
-
Sasaki Hideaki
Department Of Anesthesiology Sapporo Medical University School Of Medicine
-
Sasaki Hideaki
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Fukushima Kazuo
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
遠武 孝育
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
TERASHIMA Yoshiteru
Department of Obstetrics & Gynecology, The Jikei University School of Medicine
関連論文
- 本邦酸性湖堆積物-猪苗代湖-における有機地球化学的研究
- 酸性降水の陸水への影響および酸性陸水の生態学
- 霧島大幡池,雲仙別所ダムの酸性湖堆積物における脂質成分
- Nerve growth factor (NGF) induces increase in multi-ubiquitin chains and concomitant decrease in free ubiquitin in nuclei of PC12h
- 陸上熱水生態系の有機地球化学的研究
- 椎谷層のケロジェン特性とバイオマーカー組成
- 寺泊層のバイオマーカー組成
- Effects of Hospital and Surgeon Volumes on Operating Times, Postoperative Complications, and Length of Stay Following Laparoscopic Colectomy
- Impact of surgeon and hospital volumes on short-term postoperative complications after radical hysterectomy for cervical cancer
- Volume-Outcome Relationship in Rectal Cancer Surgery : A New Perspective
- Effects of Hospital and Surgeon Case-Volumes on Postoperative Complications and Length of Stay After Esophagectomy in Japan
- Analysis of factors affecting operating time, postoperative complications, and length of stay for total knee arthroplasty : nationwide web-based survey
- High-volume surgeons in regard to reductions in operating time, blood loss, and postoperative complications for total hip arthroplasty
- Risk-Adjusted Analyses of the Effects of Hospital and Surgeon Volumes on Postoperative Complications and the Modified Rankin Scale After Clipping of Unruptured Intracranial Aneurysms in Japan
- Influence of hospital and surgeon volumes on operative time, blood loss and perioperative complications in radical nephrectomy
- Effect of Estriol on Bone Loss in Postmenopausal Japanese Women : A Multicenter Prospective Open Study
- The Behavior of Endometrial Hyperplasia : A Prospective Study
- アカマツ起源のジテルペノイドの初期続成作用 : 長野県松本市渋池周辺の森林土壌と堆積物中のジテルペノイド
- 白駒池堆積物から推定される古環境
- 部分循環汽水湖-鹿児島県貝池-における懸濁物質と堆積物中のバクテリアバイオマーカー
- Tangential Flow Ultrafiltrationを用いた湖水中の溶存高分子量有機物の濃縮・分離と特性解析
- 無機酸性湖沼で検出されるanteiso化合物の起源について
- 北アルプス東麓河川水の水質特性と地質環境
- 屈斜路湖堆積物にみる環境変動II
- EFFECT OF TAMOXIFEN ON ULTRASTRUCTURE OF ENDOMETRIAL CARClNOMA
- Monoclonal Antibodies Spicific for NADH-Ferricyanide Reductase Domain of Spinach Leaf Nitrate Reductase
- HETERO-TRANSPLANTATION OF HUMAN ENDOMETRIAL CARCINOMA INTO NUDE MOUSE EFFECTS OF SEX STEROID HORMONES ON MORPHOLOGICAL ASPECTS OF UNDIFFERENTIATED ADENOCARCINOMA CELLS
- CIRCULATING TUMOR-ASSOCIATED ANTIGEN DETECTED BY THE MURINE MONOCLONAL ANTIBODY CF511 IN HUMAN EPITHELIAL OVARIAN CARCINOMA
- Effect of moderate osmotic treatment on the adaptation of Escherichia coli K-12 and its proline transporter mutants to hyperosmotic conditions
- Immunological Comparison of Nitrite Reductase from Different Plant Sources
- CHARACTERIZATION OF UBIQUITIN-CONJUGATING ENZYME SPECIES RESPONDING TO CELL STRESSES(Biochemistry & Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- 1P231 原子間力顕微鏡による磁気オルガネラ「マグネトソーム」の構造解析(生体膜・人工膜-構造・物性,第48回日本生物物理学会年会)
- Presence of Alternatively Spliced-Estrogen Receptor mRNA Variants in Normal Human Uterine Endometrium and Endometrial Cancer
- Purification and Some Properties of Plant Serine Acetyltransferase
- Measurement of Serine Acetyltransferase Activity in Crude Plant Extracts by a Coupled Assay System Using Cysteine Synthase
- Construction of a Chimeric Shuttle Plasmid via a Heterodimer System : Secretion of an scFv Protein from Bacillus brevis Cells Capable of Inhibiting Hemagglutination
- Trial of Labor in the Patient with a Prior Cesarean Section
- Inhibitory Effects of a Fermented "Makomo" Leaf Extract on Insoluble-glucan Synthesis by Serotype c Streptococcus mutans Glucosyltransferases
- Hepatocellular Carcinoma in a Patient with Primary Biliary Cirrhosis and Seronegativity for Markers of Hepatitis B Virus and Hepatitis C Virus : Report of a Case
- Purification and Characterization of an Oligo-isomaltosaccharide Synthase from a Streptococcus sobrinus Glucosyltransferase-I Deficient Mutant
- Investigation of Microbiological Methods to Estimating Individual Caries Risk: Evaluation of Sampling Methods and Materials
- Evidence-based guidelines for treatment of cervical cancer in Japan : Japan Society of Gynecologic Oncology (JSGO) 2007 edition
- WS5-3 Application of Laser Scanning Cytometry and Microarray Analysis to Gynecologic Oncology
- Spontaneous Rupture of the Uterus Due to Placenta Percreta at 25-Weeks' Gestation : A Case Report
- Primary Squamous Cell Carcinoma of the Ovary Associated with Primary Adenocarcinoma of the Fallopian Tube
- Prostaglandin F2α Metabofites in Plasma and Urine in Relation to Peripheral Plasma Levels of Progesterone and Estradiof-17β in the Rat During Pregnancy and Parturition
- Anti-cariogenic Properties of a Water-soluble Extract from Cacao(Food & Nutrition Sience)
- Case report of a malignant Brenner tumor with hyperestrogenism
- Mucinous Cystadenocarcinoma with Sarcoma-like Mural Nodules Arising in a Mature Cystic Teratoma of the Ovary : A Case Report
- CASE REPORT OF MALIGNANT PRIMARY NERVE SHEATH TUMOR ARISING IN THE FEMALE PELVIS
- CLlNICOPATHOLOGIC INVESTIGATION OF OVARIAN ENDOMETRIOSIS : A COMPARATIVE STUDY OF CYSTIC AND NON-CYSTIC TYPES
- CLINICOPATHOLOGIC STUDY OF ADENOSQUAMOUS CARCINOMA OF THE UTERINE CERVIX
- Bacterial Meningitis Due to Haemophilus Influenzae in Pregnancy: A Case Report
- Induction of Labor at 41 Weeks of Gestation in Uncomplicated Prolonged Pregnancy
- Mithramycin Represses MDR1 Gene Expression in Vitro, Modulating Multidrug Resistance
- Two Novel C-Glycosides of Aureolic Acid Repress Transcription of the MDR1 Gene
- 5-Hydroxy-4-oxo-L-norvaline Depletes Intracellular Glutathione : a New Modulator of Drug Resistance
- S-12 Microsatellite alterations on chromosome 18q21 and Smad4 mutations in ovarian cancers.
- EFFECTS OF SEX STEROID HORMONES ON THE HUMAN ENDOMETRIAL CARCINOMA TRANSPLANTED INTO NUDE MICE ESTROGEN PRIMING AIMED AT THE ENHANCEMENT OF TUMOR TISSUE-SENSITIVITY TO PROGESTERONE
- PRODUCTION OF STEROIDS IN ONE CASE OF GRANULOSA CELL TUMOR IN CULTURE
- Evidence-based guidelines for treatment of uterine body neoplasm in Japan : Japan Society of Gynecologic Oncology (JSGO) 2009 edition
- Nonpuerperal inversion of the uterus associated with endometrial cancer : a case report
- Long-chain anteiso compound series found in acidified freshwater lake sediments in Japan: Lake Tazawa-ko
- CYCLIC VARIATION AND DISTRIBUTION IN THE CONCENTRATION OF CYTOSOL ESTROGEN AND PROGESTERONE RECEPTORS IN THE NORMAL HUMAN UTERUS AND MYOMA
- 5α-Dihydrotestosterone “Receptor” in the Rat Hypophysis
- Analysis of the Expression and the First Exon of Aromatase mRNA in the Brains of Rat and Monkey
- Environmental Variation Recorded in the Lake Kussharo-ko Sediment
- Effects of oral atenolol on volatile anesthetic induction with sevoflurane in adults
- Safety and beneficial effect on body core temperature of a prewarmed plasma substitute-hydroxyethyl starch-during anesthesia
- 5α-Dihydrotestosterone “Receptor” in the Rat Hypothalamus
- Increased Responsiveness to Synthetic Thyrotropin-Releasing Hormone (TRH) in Androgenized Adult Rats with Special Reference to the Dose of Testosterone Propionate for Androgenization
- Age Difference in the Response to Synthetic Luteinizing Hormone-Releasing Hormone (LHRH) in Androgenized Rats with Special Reference to the Dose of Testosterone Propionate for Androgenization
- Prolactin Release by Synthetic Luteinizing Hormone-Releasing Hormone (LHRH) in Thyroidectomized-Androgenized. Adult Rats
- A STUDY ON SENSITIVITY TESTING OF OVARIAN CANCER CELLS TO ANTICANCER CHEMOTHERAPY : WITH SPECIAL REFERENCE TO THE USE OF LDH AND ITS ISOZYMES AS INDICATORS
- Zona Manipulation in an Assisted Reproductive Technologies (ART) Programme
- Relationships between stream water chemistry and catchment geology in a mountainous region in Nagano Prefecture, Japan II: mid to southern part along the Median Tectonic Line
- Clinical Trial of Daily Low-Dose Oral Etoposide for Patients with Residual or Recurrent Cancer of the Ovary or Uterus
- Cholinergic and Adrenergic Mechanisms in the Female Rat Hypothalamus with Special Reference to Reproductive Functions : Fluctuation in Choline Acetylase and Monoamine Oxidase Activities
- Clinical Evaluation of Plasma Fibronectin Level as a Biomarker of Preeclampsia
- Keratin Expression in Normal Cervical Epithelium, Cervical Intraepithelial Neoplasia and Cervical Cancer
- Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation
- Signet-Ring Cell Carcinoma of the Esophagus Associated with Barrett's Epithelium : Report of a Case
- PREFACE
- PREFACE
- Detection of secondary alkanols in Neogene sediments of the Shinjo basin, Japan : possible thermal hydration reaction products
- 日本の内陸湖沼堆積物における人為起源の多環芳香族炭化水素の分布について : 長野県仁科三湖と野尻湖
- Feasibility of eradication of mutans streptococci from oral cavities
- ISP-6-1 Prevalence and incidence of perioperative venous thromboembolism in gynecologic malignancy patients : Strategies for prevention(Group 6 Oncology 6,IS Poster,International Session)
- EFFECTS OF SEX STEROIDS ON THE CHOLINE ACETYLASE ACTIVITY IN THE HYPOTHALAMUS OF FEMALE RATS
- FLUCTUATIONS IN CHOLINE ACETYLASE ACTIVITY IN HYPOTHALAMUS OF RAT DURING ESTROUS CYCLE AND AFTER CASTRATION
- 不動池の酸性湖堆積物における脂質成分の特徴
- 六観音御池,白紫池,大浪池の酸性湖堆積物における脂肪成分の特徴
- Ca2+ sensitivity of skinned uterine muscle fibers in unilaterally pregnant rats.
- Methyl Viologen-linked Nitrite Reductase from Bean Roots
- N-allylpyrazole as a ligand. II. The preparation and reaction of some palladium(II) and platinum(II) complexes.
- Ultrasound-guided supraclavicular central venous catheterization in patients with malignant hematologic diseases
- 1-Allylpyrazole as a ligand. V. Preparation and characterization of some iron(0) and group VI metal(0) carbonyls.
- N-allylprazole as a ligand. III. The crystal and molecular structure of (1-allyl-3,5-dimethylpyrazole)copper(I) chloride.