Mithramycin Represses MDR1 Gene Expression in Vitro, Modulating Multidrug Resistance
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概要
- 論文の詳細を見る
The effect of an aureolic acid, mithramycin (MTM) on multidrug resistance (MDR) was investigated. At a concentration of 0.02-0.1 mg/ml (about 20-90 μM), MTM repressed MDR1 gene transcription of SBC-3/ADM, a MDR-phenotype subline derived from human small cell lung tumor. Under the same conditions, another aureolic acid, chromomycin A_3,showed potent cytotoxicity. FACS analysis revealed that 5 μM MTM depleted the P-glycoprotein (Pgp) and lowered the efflux activity of SBC-3/ADM cells. Furthermore, MTM sensitized the cells against adriamycin^<[○!R]>. These results suggest that MTM would be a useful modulator of MDR induced by Pgp.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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OHTAKE Yasuyuki
Foods & Pharmaceuticals Research & Development Laboratory, Asahi Breweries, Ltd.
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Ohtake Y
Foods & Pharmaceuticals Research & Development Laboratory Asahi Breweries Ltd.
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Ohtake Yasuyuki
Foods And Pharmaceuticals Research And Development Laboratory Asahi Breweries Ltd.
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Tagashira Motoyuki
Foods And Pharmaceuticals Research And Development Laboratory Asahi Breweries Ltd.
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Tagashira Motoyuki
Central Research Laboratories Asahi Breweries Ltd.
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Isonishi Seiji
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Kitagawa T
Kobe Gakuin Univ. Kobe Jpn
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KITAGAWA Takanori
Foods and Pharmaceuticals Research and Development Laboratory, Asahi Breweries Ltd.,
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ISONISHI Seiji
Gynecology, The Jikei University School of Medicine
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OKAMOTO Aikou
Gynecology, The Jikei University School of Medicine
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OCHIAI Kazunori
Gynecology, The Jikei University School of Medicine
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Okamoto Aikou
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Ochiai Kazunori
Department Of Obstetrics And Gynecology Department Of Clinical Oncology The Jikei University School
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