Two Novel C-Glycosides of Aureolic Acid Repress Transcription of the MDR1 Gene
スポンサーリンク
概要
- 論文の詳細を見る
In the search for compounds which repress MDR1 gene expression, two novel aryl C-glycosides were isolated from a broth of Streptomyces sp. They had the characteristic structure of a dideoxy-carbohydrate (oliose or olivose) linked directly to chromomycinone, an aglycone of aureolic acids. Further investigation revealed that they were artifacts yielded from an aureolic acid mithramycin. Acid and methanol were necessary to yield the C-glycosides. This reaction would contribute to the design of useful aryl C-glycosides.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
-
OCHIAI Kazunori
Department of Obstetrics and Gynecology, Jikei University School of Medicine
-
ISONISHI Seiji
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Aoto Hospital
-
OHTAKE Yasuyuki
Foods & Pharmaceuticals Research & Development Laboratory, Asahi Breweries, Ltd.
-
Ohtake Y
Foods & Pharmaceuticals Research & Development Laboratory Asahi Breweries Ltd.
-
Ohtake Yasuyuki
Foods And Pharmaceuticals Research And Development Laboratory Asahi Breweries Ltd.
-
Tagashira Motoyuki
Foods And Pharmaceuticals Research And Development Laboratory Asahi Breweries Ltd.
-
Tagashira Motoyuki
Central Research Laboratories Asahi Breweries Ltd.
-
Isonishi Seiji
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Isonishi Seiji
Department Of Obstetrics And Gynecology Jikei University Daisan Hospital
-
Kitagawa T
Kobe Gakuin Univ. Kobe Jpn
-
KITAGAWA Takanori
Foods and Pharmaceuticals Research and Development Laboratory, Asahi Breweries Ltd.,
-
NOZATO Naoko
Foods and Pharmaceuticals Research and Development Laboratory, Asahi Breweries, Ltd.,
-
OKAMOTO Aikou
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
-
Okamoto Aikou
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
-
Nozato Naoko
Foods And Pharmaceuticals Research And Development Laboratory Asahi Breweries Ltd.
-
Ochiai Kazunori
Department Of Obstetrics And Gynecology Department Of Clinical Oncology The Jikei University School
関連論文
- Inhibition by Hop Bract Polyphenols of Cellular Adherence and Water-insoluble Glucan Synthesis of Mutans Streptococci
- Effects of Hospital and Surgeon Volumes on Operating Times, Postoperative Complications, and Length of Stay Following Laparoscopic Colectomy
- Impact of surgeon and hospital volumes on short-term postoperative complications after radical hysterectomy for cervical cancer
- Volume-Outcome Relationship in Rectal Cancer Surgery : A New Perspective
- Effects of Hospital and Surgeon Case-Volumes on Postoperative Complications and Length of Stay After Esophagectomy in Japan
- Analysis of factors affecting operating time, postoperative complications, and length of stay for total knee arthroplasty : nationwide web-based survey
- High-volume surgeons in regard to reductions in operating time, blood loss, and postoperative complications for total hip arthroplasty
- Risk-Adjusted Analyses of the Effects of Hospital and Surgeon Volumes on Postoperative Complications and the Modified Rankin Scale After Clipping of Unruptured Intracranial Aneurysms in Japan
- Influence of hospital and surgeon volumes on operative time, blood loss and perioperative complications in radical nephrectomy
- Enzyme Immunoassay for a Characteristic Protein in the Animal Crude Drug Lumbricus
- Application of a Licorice Root Specific Protein to a General Method for the Assay of Licorice Root Components in Traditional Chinese Medicines
- Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman
- Two cases of epidural anesthesia-associated postoperative decubitus
- Analysis of Transactivation Region of Elf-1 by Using a Yeast One-hybrid System(Biochemistry & Molecular Biology)
- Molecular Cloning of Rat USF2 cDNA and Characterization of Splicing Variants
- Splice Isoforms of Transcription Factor Elf-1 Affecting Its Regulatory Function in Transcription-Molecular Cloning of Rat Elf-1
- EFFECT OF TAMOXIFEN ON ULTRASTRUCTURE OF ENDOMETRIAL CARClNOMA
- HETERO-TRANSPLANTATION OF HUMAN ENDOMETRIAL CARCINOMA INTO NUDE MOUSE EFFECTS OF SEX STEROID HORMONES ON MORPHOLOGICAL ASPECTS OF UNDIFFERENTIATED ADENOCARCINOMA CELLS
- A General Enzyme Immunoassay for the licorice Root Component Contained in Traditional Chinese Medicines
- A New Method for the Detection and Quantitative Measurement of the Contents of Trichosanthes Root Component Composing Chinese Traditional Medicines
- Evidence-based guidelines for treatment of cervical cancer in Japan : Japan Society of Gynecologic Oncology (JSGO) 2007 edition
- Expression of the Glutathione Synthetase Gene of Escherishia coli B in Saccharomyces cerevisiae
- The Expression of the γ-Glutamylcysteine Synthetase Gene of Escherichia coli B in Saccharomyces cerevisiae(Biological Chemistry)
- WS5-3 Application of Laser Scanning Cytometry and Microarray Analysis to Gynecologic Oncology
- Synthesis and Root Growth-Inhibitory Activity of 2- and 3-(Haloacetylamino)-3-(2-furyl)propanoic Acids
- Mithramycin Represses MDR1 Gene Expression in Vitro, Modulating Multidrug Resistance
- Two Novel C-Glycosides of Aureolic Acid Repress Transcription of the MDR1 Gene
- Preparation of Monoclonal Antibodies against N-(γ-Maleimidobutyryloxy)succinimide (GMBS)-Conjugated Acetylspermine,and Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for N^1,N^-Diacetylspermine
- Development and Application of a Sandwich Enzyme Immunoassay for Glycyrrhizae Radix Protein (GRP) Using Monoclonal Antibodies
- Specificities of Five Kinds of Antisera Produced against Crude Drugs, Pinellia Tuber, Hoelen, Glycyrrhizae Radix, Trichosanthes Root and Panax Ginseng
- Determination of Urinary Acetylpolyanines by a Monclonal Antiboby-Based Enzyme-Linked Immunosorbent Assay (ELISA)
- 5-Hydroxy-4-oxo-L-norvaline Depletes Intracellular Glutathione : a New Modulator of Drug Resistance
- S-12 Microsatellite alterations on chromosome 18q21 and Smad4 mutations in ovarian cancers.
- Construction of the Transcriptional and Translational Signals-cloning Vector in Saccharomyces cerevisiae(Biological Chemistry)
- Evidence-based guidelines for treatment of uterine body neoplasm in Japan : Japan Society of Gynecologic Oncology (JSGO) 2009 edition
- Analysis of fetal DNA from maternal peripheral blood by lectin-polymerase chain reaction-single strand conformation polymorphism
- Antioxidative Activity of Hop Bitter Acids and Their Analogues
- Nonpuerperal inversion of the uterus associated with endometrial cancer : a case report
- CYCLIC VARIATION AND DISTRIBUTION IN THE CONCENTRATION OF CYTOSOL ESTROGEN AND PROGESTERONE RECEPTORS IN THE NORMAL HUMAN UTERUS AND MYOMA
- Small cell carcinoma of the ovary : clinical and biological study
- Primary chemotherapy-associated effect of second-line chemotherapy on survival of patients with advanced ovarian cancer
- P-IS-39 Primary chemotherapy associated effect of 2nd-line chemotherapy on survival of advanced ovarian cancer(Oncology 10,Group 97,International Session)
- ISP-6-1 Prevalence and incidence of perioperative venous thromboembolism in gynecologic malignancy patients : Strategies for prevention(Group 6 Oncology 6,IS Poster,International Session)
- Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells