EFFECT OF TAMOXIFEN ON ULTRASTRUCTURE OF ENDOMETRIAL CARClNOMA
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概要
- 論文の詳細を見る
Tamoxifenの子宮内膜癌への作用を解明する為に,子宮内膜癌患者5名(分化型腺癌3例,未分化型腺癌2例)に対し,Tamoxifen20mg/dayを7日間経口投与し,投与前後の内膜癌組織を超微形態学的に比較検討し以下の結果を得た.(1)細胞及び核は,丸みをおび,やや腫大傾向を示した.(2)ミトコンドリア・RER・ゴルジ装置等の細胞内小器管の発達が観察された.(3)細胞質内グリコーゲン穎粒の増加は,観察されなかった.しかし同時に,特に未分化型腺癌例においては,反応性に乏しい細胞の存在も観察された.以上より,Tamoxifenは子宮内膜癌組織に対し機能的分化の方向への導入を行う事,及びグリコーゲン代謝を阻害する事に依って抗腫瘍効果を現わすものと示唆された.
- 社団法人日本産科婦人科学会の論文
- 1987-04-01
著者
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天野 信人
国立大蔵病院
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OCHIAI Kazunori
Department of Obstetrics and Gynecology, Jikei University School of Medicine
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KATO Junzo
Department of Obstetrics and Gynecology, Yamanashi Medical University
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天野 信人
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
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TOHTAKE Takayasu
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
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TERASHIMA Yoshiteru
Department of Obstetrics and Gynecology, The Jikei University School of Medicine
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Kato J
Department Of Obstetrics And Gyleecology Yamanashi Medical University
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Terashima Y
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Terashima Yoshiteru
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Ochiai Kazunori
Department Of Obstetrics And Gynecology Department Of Clinical Oncology The Jikei University School
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Ochiai K
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Tohtake T
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Tohtake Takayasu
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Kato Junzo
Department Of Obstetrics And Gyleecology Yamanashi Medical University
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TERASHIMA Yoshiteru
Department of Obstetrics & Gynecology, The Jikei University School of Medicine
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