Interferon-α投与により生児を獲得した本態性血小板血症合併妊娠の1例

概要

論文の詳細を見る
We report a case of pregnancy complicated by essential thrombocythemia(ET)successfully treated with interferon-α(IFN-α). The patient, 28-year-old woman, was diagnosed with ET at 22-years of age and had a history of two miscarriages with no treatment for ET. Aspirin(100mg/day)was started two months prior to the present pregnancy. At the 6th week of gestation, because her platelet count was 186.9×10^4/μl IFN-α was started at a dose of 21 million units(MU)per week, and later increased to 36 MU per week. At the 24th week of gestation, the leukocyte count, Hb and platelet count were 4, 000/μl, 8.7g/dl and 23.6×10^4/μl, respectively. IFN-α was tapered off to 6 MU per week. At the 38th week of gestation, she had an uncomplicated vaginal delivery with a platelet count of 33×10^4/μl.The infant was a healthy female weighing 2, 720g. No abnormal findings were observed in the placenta. The platelet count of cord blood was 28.4×10^4/μl.Our case provides additional information indicating that IFN-α is clinically effective in preventing recurrent abortion associated with ET, with no significant adverse effect.
社団法人日本産科婦人科学会の論文
2002-01-01