IMMUNODEPRESSIVE EFFECT OF SERA OF CANCER PATIENTS

概要

論文の詳細を見る
To demonstrate the immunodepressive effect of the sera of cancer patients, the in vitro response of normal lymphocytes to phytohaemagglutinin (PHA) or to allogeneic lymphocytes was estimated in the presence of sera of various patients with pelvic cancer. Exchange of sera between healthy individuals caused no ABO-group-related effect on normal lymphocyte response. Serum from patients with advanced cancer had a strong depressive effect on normal lymphocyte response, and this overcame the effect of healthy serum mixed in the culture. Serum-induced depression was demonstrated in 46 of 54 (87%) patients with active cancer and in all patients with recurrent cancer using lymphocyte response to PHA, and in 23 of 28 (82%) cancer patients and 7 of 8 (87%) patients with recurrent cancer using the mixed lymphocyte reaction. Almost no depression was found in the sera of 25 patients with cervical carcinoma in situ and in 70 follow-up patients with good prognoses after therapy for invasive carcinoma. The results indicate that the immunodepressive effect of the sera of cancer patients might be directly related to the presence of active cancer in vivo, and the possible mechanism of this is briefly discussed.
社団法人日本産科婦人科学会の論文
1977-04-01