INFLUENCE OF MATERNAL HYPEROXIA OR HYPERCARBIA ON THE HEMODYNAMICS OF THE PLACENTA AND FETAL BRAIN

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ynopsis pregnant rabbits were subjected to inhalation of different gases, and the changes in placentalblood now (PBF), fetal heart rate (HR), and fetal cerebral blood now (CBF) associated with the changes inmaternal blood gas levels were studied The results are given belowIn maternal hyperoxia, maternal blood pressure (BP) was not much innuenced and PBF remainedunchanged or was slightly decreased when the PCO2 level was not varied or when it was lowered Incontrast, not only maternal BP but also PBF was increased when the PCO2 level was elevated In theabsence of a conspicuous increase in PCO2, neither fetal HR nor CBF varied, regardless of PBFBoth maternal BP and PBF were increased in mild to moderate maternal hypoxla (PO2>4ommHg) anddecreased in severe hypoxia (PO2 <3ommHg) The decreasing trend of fetal HR or CBF was strengthenedas maternal hypoxia was intensined An obvious decrease in either parameter was observed in severematernal hypoxia (PO2<3ommHg) Fetal HR and CBF were well maintained in hypoxic dams withincreased PBF as compared with those with unchanged or decreased PBF. The higher the PCO2 level orthe lower the pH value, the more was fetal bradycardia that was apt to occur, even in a mildly hypoxicstate
社団法人日本産科婦人科学会の論文
1986-10-01