^<99m>Tc利用による市販坐剤の薬品の溶出と放出特性

概要

論文の詳細を見る
A method was developed to determine the dissolution and release of ingredients of suppositories by using ^<99m>Tc, a short-life radionuclide, as a tracer. Suppositories on the market were melted at as low temperature as 45-50°, and poured into a plastic suppository tray. Tracer was added to the product which was cooled to 4°to remold. The resultant product was used as suppositories for testing. The melted suppositories contain in each 20g Na^<99m>TcO_4 about 500μCi and sulpyrine 500 mg. Remolded suppositories weigh about 1.3g each. The ingredient-releasing characteristics were determined in terms of the amount of ^<99m>Tc in the suppositories released into water at 37°through cellulose membrane in the form of ^<99m>TcO_4-. The dissolution of ingredients was measured in terms of the amount of ^<99m>TcO_4- eluated into water at 37°without passing through the membrane. As a result, significant difference in dissolution and relasing was observed not only among the same category of drugs but among same brand of drugs.
日本医療薬学会の論文
1980-08-20