^<113m>Inの混合度測定への応用(第6報)坐剤その1主成分へのラベル法

概要

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In preparing suppositories by the fusion method, when the active ingredients are insoluble in bases, it is necessary to pour the mixture into a mold with stirring so as to allow the active ingredient to be homogeneously dispersed. The relation between the suppository preparation methods and distribution of the active ingredients has been little elucidated because there is a difficulty in separating and assaying the active ingredients. In the present study, such a method was examined and a suppository was prepared by labeling zinc oxide with ^<113m>In, a short-1ived isotope, and mixing it with cacao butter, and the distribution of zinc oxide was determined in terms of radioactivity. As a result, a method was developed which determines the distribution of zinc oxide, with ^<113m>In.Fe(OH)_3 of the particle size of 10 to 100 nm as tracer (Chart 1). Sixty suppositories containing 10% of zinc oxide were measured by this method, and the coefficients of radioactivity variation were 3.3.% and 6.57% for the suppository poured with and without stirring, respectively.
社団法人日本薬学会の論文
1974-01-25