^<113m>Inの混合度測定への応用(第7報)散剤その6倍散調製における成分の均一性に及ぼす賦形剤の影響

概要

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Effect of difference in types of fillers on the homogeneity of the principal drug in triturations was examined by using fine phenobarbital labeled with ^<113m>In as the test drug. The test fillers were crystalline lactose with particle diameter in the range of 74-149 μ(I), fine lactose mixed it crystalline lactose (II), and corn starch mixed with fine lactose (III), each of which was used in preparing 10% ^<113m>In-phenobarbital powder. Mixing time was shortest with the test filler II. The mixture with the test filler I took the longest time to be prepared besides being not perfect. The degree of separation of ^<113m>In-phenobarbital by tapping was the highest in the mixture with III, and lowest in that with II. In the mixture with I or III, tapping decreased ^<113m>In-phenobarbital at the lower part of the vessel and its increase at the upper part, decrease in the lower layer being particularly marked. These results show that II, easily mixed with the principal drug and effective in maintaining its homogeneity, is the most suitable filler for trituration.
社団法人日本薬学会の論文
1974-02-25