流動層造粒乳糖の混合性の評価

概要

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Experiments were carried out for the evaluation of mixing properties of some lactose granules with fluidized bed, using powdered lactose, crystallline lactose, cornstarch, and synthetic aluminium silicate. Medicinal powders, group A, were labeled with radionuclide indium-113m. Five kinds of preparations with different physical properties were used as medicinal lactose granules with fluidized bed, group B. Group A was mixed with B with use of YMQ-type dispensing mixer, 3 times for 5 sec each. A-B mixing ratio was 1:4, 1:2, 1:1, 2:1 and 4:1. The results indicated that fluidized bed granulations with the following physical properties showed good mixing with medicinal powders : Apparent density 0.59g/cm^3, angle of repose 38°,escapability 13%, degree of decrease in apparent specific volume O.16. Distribution of particle size : 2.4% (>200meshes), 26.6% (100-200 meshes), 33.8% (65-100 meshes), 33.1% (48-65 meshes), 4.2% (36-48 meshes).
日本医療薬学会の論文
1979-08-20