^<113m>Inの混合度測定への応用(第8報)坐剤その2 主成分の均一性に及ぼす溶融温度の影響

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An examination was made on the method for determination of the optimal melting temperature at which the mixture of main active ingredients and a base is poured into molds for preparing suppositories by the fusion method. The mixture was prepared by labeling zinc oxide with ^<113m>In・Fe(OH)_3,and mixing it with cacao butter, and distribution of zinc oxide was determined from radioactivity. Distribution of the active ingredient in mixtures melted at 40 to 60° showed a coefficient of variation not higher than 1.0% immediately after cessation of stirring and about 2.5% 5 min later. Coefficient of variation of the active ingredient was higher 10 min after cessation of stirring and thereafter, when the melting temperature was higher. Further, the higher the melting temperature, the larger was the difference in the content of the active ingredient between the upper and bottom layer of the mixture. In the mixture melted at 40°, virtually no difference was noted in the content of the active ingredient between the upper and bottom layers even 50 min after cessation of stirring, but in the mixture melted at 60° there was about two-fold difference in the content between the two layers 30 min after cessation of stirring and about 3-fold difference 50 min later. From these data, a method was established which would permit rapid determination of the distribution of active ingredienst in a mixture of active ingredients and a base.
社団法人日本薬学会の論文
1974-11-25

^<113m>Inの混合度測定への応用(第8報)坐剤その2 主成分の均一性に及ぼす溶融温度の影響

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