スルピリン坐剤とアミノピリン坐剤の調製

概要

論文の詳細を見る
Methods of sulpyrine and aminopyrine suppositories labeled with a short-lived isotope^<113m> In were studied. The distribution of ^<113m>In-sulpyrine in the mixture of ^<113m>In-sulpyrine and cacao butter at 40°showed a coefficient of variation (C.V.) at about 1% immediately after cessaion of stirring, 4% 10 min. after and 31% 50 min. after. When the melting temperature of the mixture was raised, C. V. of ^<113m>In-sulpyrine rose. The distribution of ^<113m>In-aminopyrine was not changed with melting temperature and C. V. was within 10% at various temperatures of the mixture. When the mixture of the active ingredients and the bases was poured into the suppository mold, C. V. of the active ingredients was large with ^<113m>In-sulpyrine suppositories and small with ^<113m>In-aminopyrine. Therefore, in the preparation of the sulpyrine suppositories, the mixture should be poured into a mold with stirring at the temperature not higher than 40°. In the preparation of the aminopyrine suppositories, homogeneous products are available by pouring the mixture into a mold with stirrign at 40-50°.
日本医療薬学会の論文
1980-02-20