炎光光度計による坐剤中のスルピリンの簡易定量法

概要

論文の詳細を見る
A simple method for determination of sulpyrine content of suppositories with flame photometer was evaluated with use of 5 types of suppositories and one commercial suppository. The 5 suppositories were prepared by mixing 5 to 20% sulpyrine with cacao butter and Witepsol H-15 as bases. Each suppository was taken in a test tube containing distilled water, and shaken at 37℃ for 2 hours. After cooling at room temperature, the solidified base was filtered away. Sodium ion concentration in the remaining water layer was measured with flame photometer. The results obtained by this method were consistent with those by colorimetric assay, and the coefficients of variation were 1.0 to 3.1%. The distribution of sulpyrine in a suppository was also determined by this method. Thus, it can be concluded that this simple method provides a useful tool for the quality test in hospital pharmacy.
日本医療薬学会の論文
1984-08-20