錠剤及びカプセル剤の調剤時における剤形変更に関する知見

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The alteration of dosage forms in dispensing of tablets and capsules was reviewed by using outpatients' prescriptions from Jan. to Mar. 1988. It was showed that the frequency of alteration was about 6% of total prescriptions. The alteration was classified into 5 types of pattern by a checking prescription, which included 44.1% for grinding tablets and opening capsules and residues for changing to the generics of the alternative dosage forms which were already purchased. The frequency of alteration was especially high in Pediatrics and Psychiatry in the comparison with clinical departments. There were no significant differences between sex. On age, children under 5 years old had many alterations particularly, which tended to decrease gradually according to an increase of age. It was suggested that the specific patients always needed the alteration. It was suspected that there were reasons such as the necessity of controlled low doses and the difficulty to swallow as a physiological problem from low age, the necessity of doctors' concealment of doses, kinds and name of drugs to the patients, and the preference of patients in the background. Moreover, it was suspected that the alteration should be at least done under 6 years old about low age patients on the internal rule of dispensing, and those ages corresponded to ages of patients involved which the number had shown more than 20% of the total number of prescription patients in each age.
日本医療薬学会の論文
1989-08-20

錠剤及びカプセル剤の調剤時における剤形変更に関する知見

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