臨床における薬学の展開 : 15年の軌跡

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In this review, we outline the new developments in pharmaceutical practice, education and research achieved by the Department of Pharmacy of the University of Tokyo Hospital in the 15 years from 1990 to 2004. In pharmaceutical practice, we created 1) a computer-aided total dispensing system linked to a system for the efficient examination of prescriptions, a parallel dispensing system for countable and uncountable drugs incorporating several automatic dispensing support devices, and a drug usage consultation system for outpatients using Drug Information Sheets, Drug Information Cards and leaflets, and 2) a total dispensing system for injectable drugs including those for intravenous hyperalimentation (IVH) for inpatients and home parenteral nutrition (HPN). In the area of new dosage forms, we developed several original non-commercial, high level medications designed to improve the QOL of patients, such as buprenorphine sublingual tablets and suppositories and retmoic acid aqueous gel ointment. We also started providing consultation to patients in wards and support for raising the quality of medical treatment, and created a drug information system for medical staff and patients. Other achievements were the development of a therapeutic drug monitoring system (TDM) for organ transplantation and a total clinical research trial management system based on new GCP. In the area of education, we created a pharmaceutical education program for bed-side training (BST) for undergraduate students of the Faculty of Medicine and a training program on pharmaceutical practice for undergraduate students of the Faculty of Pharmaceutical Sciences. We also developed a practical training program for newly graduated trainee pharmacists and a continuing education program for post-graduate pharmacists. In the area of clinical research, we review the following four major projects : 1)Drug interactions between the new quinolone antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), 2) PK/PD analysis of QT prolongation induced by drugs for non-cardiovascular diseases, 3) Quantitative evaluation of pharmacological effects and adverse effects of β- blocking agents based on the receptor occupancy theory, and 4) Clinical research on genotypmg of drug metabolizing enzymes for the purpose of creating tailor-made treatments
日本医療薬学会の論文
2005-01-10

臨床における薬学の展開 : 15年の軌跡

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