内科領域における向神経薬治療に関する考察 : NC 123治療を中心として

概要

論文の詳細を見る
In relation to a series of studies on psychosomatic aspects of diseases in the filed of internal medicine, the present report deals with a clinical study on the treatment with tranquilizers, with special reference to a phonothiazine deribative NC 124. Twenty patients with psychosomatic diseases were treated with NC 123 in daily doses of from 15 to 20mg for not less than three weeks.The effect of the drug was evaluated with the double-blind technique according to our criteria for the tranquilizer effects reported previously.NC 123 was found effective in 65% of cases studied, and the therapeutic spectrum of the drug covered various anxiety symptoms, especially those of moderate degrees. The improvements of clinical target symptoms achieved by the NC 123 treatment safisfactorilly paralleled the stabillization of the results of the psychological surveys (Taylor-MAS, and Rorschach test) and the observation of behaviors. The side effects observed were mild sleepinesses and nasal congestions found in three cases. In the present series of cases, there was no statistically significant difference of NC 123 effects between ages, sexes, presence and absence of neurotism and between types of mecholyl responses.The proposed indications and therapeutic spectra of several, Tranquilizers, as well as the psychosomatic changes induced by the tranquilizer treatments, were discussed.
日本心身医学会の論文
1968-04-01