内科領域疾患に対するBromazepamの臨床薬理学的研究(第1報)

概要

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As a series of the clinical-pharmacological studies of psychotropic drugs, the present report deals with the influence of Bromazepam 15mg/day administration to 37 patients suffering from either various psychosomatic diseases or other conditions.Taking the double-blind cross-over method, we tried to display the result numerically. As a reslt, we found that Bromazepam had antidepressant effect and strong sleep inducing and muscle relasxant effects as well as excellent anti-anxiety effect.Side effects were observed in 22 cases (60%), and the administration was stopped because of that in 6 cases. Besides sleepiness, muscle relaxation symptoms such as disturbance in gait, etc. were observed and paradox phenomena such as excitation, anxiety, etc. were observed in a few cases.Although the side effects were diminished rapidly by decreasing the dose in some of the cases, we think that the dose of 15mg/day is too much for habitual use in the field of internal medicine. Then it is necessary for us to study the general dose of the drug hereafter.
日本心身医学会の論文
1971-10-01