内科領域疾患に対するBromazepamの臨床薬理学的研究(第2報)

概要

論文の詳細を見る
In a previous study carried out as a part of clinico-pharmacological studies on Bromazepam, we have reported that Bromazepam had an antidepressant effect and a potent hypnotic effect, in addition to a muscle relaxant effect and a potent anxiolytic effect. The present report deals with a study on dose-response of this drug, carried out as a multi-clinical trial of the double-blind cross-over method. The minimal effective dosis, or ED_25,as well as ED_50,was estimated, and a dose level which might cause side-effects in 25% of patients was also estimated. From these values, the upper limit of practical dose, or a dose by which an incidence of side-effects in 50% of patients might be expected, was calculated. It was concluded that the optimal daily dose of this drug as an anxiolytic agent might fall between 6 mg and 10 mg.
日本心身医学会の論文
1973-02-01