Studies on Serum Alpha-lipoprotein in Hyperlipidemia

概要

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Significant decrease of α-lipoprotein concentration was noted in subjects with hyperlipidemia of type IV of WHO classification compared with those in controls and in hyperlipidemia of type Ha and type llb. Ratio between concentrations of phospholipid and total cholesterol in α-lipoprotein fraction separated by centrifugation of the mixture of serum and heparin-CaCl2 solution, was higher in subjects with hyperlipidemia of type IV than those in controls and in the other type hyperlipidemic subjects. Decrease of lecithin and increase of lyso lecithin were also noted in the phospholipid fraction of sera from subjects with hyperlipidemia of type IV compared with those in controls and in the other type hyperlipidemias. These differences in the lipid constituents, however, were unable to see in HDL2, 3 fraction of sera from controls and hyperlipidemic subjects. Therefore, it is suspected that the discrepancies of these results might be due to the absence of very high density lipoprotein (d>1, 201) in HDL2, 3. There found no differences on the electrophoretical patterns of apo-protein in HDL2, 3 between controls and the hyperlipidemic subjects.
Japan Society of Clinical Chemistryの論文