卵巣摘出によるカニクイザル顎骨の変化に関するX線CTを用いた研究

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We examined by computed tomography (CT) whether ovariectomy induces bone loss in the jaw in monkeys. Eighteen cynomolgus female monkeyswith an estimated age of 9 to 15 years were divided into two groups : a group that underwent ovariectomy (OVX group, n=9) and a sham-operated group (SHAM group, n=9). Animals in each group were maintained under similar conditions according to the appropriate guidelines of the National Institutes of Health U.S.A.. Two years after the operation, the animals were killed, and the maxillo-facial bones were dissected. Each bone was examined by CT, followed bythe determination of CT values in five different regions, i.e., root apex of the maxillary lateral incisor, mandibular condyle, root apex of the mandibular first premolar and root apex of the mandibular second molar, and chin. First we examined the reproducibility of CT values in these regions, and three regions with good reproducibility (mandibular condyle, root apex of the mandibular first premolar and chin) were chosen for the examination. All CT values in these regions were lower in the OVX group than in the SHAM group (2-way ANOVA, p<0.05). A statistically significant difference was observed in the mandibular condyle (Fisher's PLSD multiple comparison test, p<0.05), but not in the other regions studied. These results suggest that ovariectomy reduces bone mineral content in the jaw, but the magnitude of such loss varies from region to region.OVXcynomolgus monkeyCT value
東北大学の論文
2003-06-30

卵巣摘出によるカニクイザル顎骨の変化に関するX線CTを用いた研究

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