卵巣摘出によるカニクイザル顎骨の骨塩量の変化

概要

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We investigated changes in the bone mineral content (BMC) of the maxilla and mandible after ovariectomy in female monkeys as assessed on lateral cephalograms. Eighteen cynomolgus monkeys (estimated age : 9-15 years old) were divided into two groups : a group that underwent ovariectomy (OVX group, n=9) and a sham-operated group (SHAM group, n=9). Two years after the surgical operation, all animals were killed, and lateral cephalograms of oro-facial specimens of the animals were obtained. The BMCs of 11 regions in the maxilla and mandible were determined by densitometric analysis of cephalograms. An aluminium step wedge was used as a standard. Ovariectomy decreased the BMC of the maxillary and mandibular bones. However, the decrease in BMC varied from region to region : the BMC significantly decreased in the alveolar bone under the premolar and molars and in the marginal bone of the mandibular angle, which might be directly subjected to mechanical stress. In contrast, the BMC did not significantly decrease in other sites considered to be under less or indirect mechanical stress. These results suggest that OVX could lead to bone loss in some sites of the maxilla and mandible, and that the magnitude of such loss might be influenced by the degree of mechanical stress.OVXcynomolgus monkeyosteoporosisbone mineral contentlateral cephalogram
東北大学の論文
2003-06-30