<原著>口腔扁平上皮癌,とくに舌癌におけるUlex europeus I レクチンの検討

概要

論文の詳細を見る
The distribution of Ulex europeus agglutinin (UEA-I) lectin binding sites in squamous cell carcinomas of the tongue was studied. The UEA-I lectin binding sites were revealed using the immunoperoxidase method. Formalin-fixed and paraffin-embedded tissues were employed. The cell membranes of the spinous layer stained positively in normal lingual mucosa, whereas the basal cells reacted negatively. The UEA-I binding sites were present in all of the squamous cell carcinomas of the tongue. The staining intensity in cancerous lesions showed a considerable variation. The staining intensities in poorly differentiated squamous cell carcinomas were weaker than in moderately and well differentiated squamous cell carcinomas. The localization of UEA-I binding was on the cell membranes and also in the cytoplasm of the poorly differentiated squamous cell carcinomas. Moderately and well differentiated squamous cell carcinomas showed more intense staining and localization of UEA-I binding on the cell membranes. The present study suggests that the staining intensities of UEA-I lectin binding tend to correlate with the degree of differentiation of squamous cell carcinomas.
北海道医療大学の論文
1984-06-30