<原著>口腔上皮ならびに口腔扁平上皮癌におけるアポートシスに関する病理組織学的研究 : 特にLewis Y糖鎖発現と,DNA nick end labeling法との比較

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Apoptosis (programmed cell death) detection by DNA fragmentation is well known. Recently, a method to identify the phenomenon in tissue sections was developed as a DNA nick end labeling method. Following this technique, the expression of blood group antigen Lewis Y (Le^Y) was reported to correspond to apoptosis. We examined the localization of Le^Yantigen in squamous cell carcinomas and oral epithelia and compared it with results of the DNA nick end labeling method. In normal oral epithelia, signals by the DNA nick end labeling method agreed with the apoptosis, i.e. in nuclei in the subcornified layer with parakeratosis. The Le^Y localized at the prickle cell layer was not real apoptosis. The positive staining in the salivary gland was not acceptable as apoptosis. In squamous cell carcinomas, suggestive colocalization may support Le^Y to be an apoptosis related antigen.
1993-12-31