口腔癌における血液型物質 (A, B, H) の局在

概要

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The blood group substances A, B and H are examples of cell surface glycolipids and glycoproteins in which the antigenic determinants are located near the carbohydrate chains of these molecules. A and B antigens are synthesized by the addition of terminal carbohydrates to a precursor substance with blood group H activity. The distribution of blood group carbohydrate chains with antigens A, B and H specificity was studied in 56 human oral squamous cell carcinomas. The cancerous lesions examined were obtained from 21 blood group A, 12 blood group B, 7 blood group AB, and 16 blood group O persons. 3 blood group antigens are evaluated in serial sections by immunohistochemical techniques with monoclonal antibodies to A, B and H antigen.<BR>In conclusion, blood A and B substances are lost and their precursor, H antigen, is accumulated in the majority of oral squamous cell carcinomas. The staining intensities of blood group substance H tend to correlate with the degree of differentiation of squamous cell carcinoma. Therefore the process of ontogenesis of a blood group carbohydrate chain occurs as step by step elongation, but such a development of carbohydrate chain is considered to be blocked in the process of oncogenesis.<BR>Investigation of blood group antigens A, B and H may be a useful marker in diagnosis of oral squamous cell carcinomas.