<原著>ワラビ発癌性に関する研究 : 当別町周辺から採集されたワラビで飼育したラットの腸管に発生した腫瘍の形態学的研究第1報悪性線維性組織球腫の発生

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Bracken is known to induce intestinal and urinary bladder tumors in the rats fed with bracken. Hirono et al reported that bracken collected in the district around Tobetsu-cho, Ishikari-Gun, Hokkaido, was more potent in oncogenecity than bracken gathered in the mountain area of the Gifu prefecture. The present study was conducted to elucidate the histogenesis of intestinal tumors thus induced. 5 weeks old male rats were fed pellets containing 33% of dried powder of bracken in the rats basal diet. The bracken was harvested in the area around Tobetsu-cho. The pellets were prepared according to the Hirono's method. All of 16 rats, died or were sacraficed 188 days and after the feeding period, showed multiple tumors in the anal 10 cm of ileum. This finding confirmed the experimental result reported by Hirono et al who found ileal tumors in the rat survining beyond 7 months after the start of feeding by the diet containing Tobetsu-cho bracken. Ileal tumors developed in two ways : one was a polypoid epithelial tumor and the other protruded through the muscle layer to the serosal surface to form a ball-like tumor mass. The latter tumor was a mesenchymal tumor or an invading epithelial tumor accompaned by mesenchymal proliferation. In this study special attention was paid to the histopathology of mesenchymal tumor. The tumor was composed of fibrobroblast-like cells arranged in a storiform pattern, histiocyte-like cells of various forms and bizarre giant cells and these cells presented a plemorphic pattern. These tumor cells were electron-microscopically characterized. A number of mitotic cells including atypical forms were observed. The mesenchymal tumor was diagnosed as malignant fibrous histiocytoma, MFH. Invasion and metastasis of MFH in the mesenterium and its lymph nodes were noted in 2 animals. An investigation of lesions preceding MFH formation is now in progress.
北海道医療大学の論文
1982-12-31

<原著>ワラビ発癌性に関する研究 : 当別町周辺から採集されたワラビで飼育したラットの腸管に発生した腫瘍の形態学的研究第1報悪性線維性組織球腫の発生

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<原著>ワラビ発癌性に関する研究 : 当別町周辺から採集されたワラビで飼育したラットの腸管に発生した腫瘍の形態学的研究 第1報悪性線維性組織球腫の発生

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<原著>ワラビ発癌性に関する研究 : 当別町周辺から採集されたワラビで飼育したラットの腸管に発生した腫瘍の形態学的研究第1報悪性線維性組織球腫の発生