<原著>腸内細菌叢に関する腹部実験外科学

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In the germfree isolator of Nortre Dame styles, where there are not any bacteria, of course intestinal flora, the cellulose in foods absorbs the bile acids and endotoxin of gram negative bacilli in feces of conventional mice which was given to germfree mice with diets transferred after sterilization of nuclear energy into germfree isolator during passing through the inferior digestive tracts. If we observe both microscopically and macroscopically the cecum wall of germfree mice, the facts can be recognized that enough cellulose of foods induces the enlargement of gnotobiotic cecum that we call megacecum inside the germfree isolator, and furtltermore influence on microscopic findings of cecum. We must not ignore the formation of micro-thrombus due to pathogenous bacilli in intestinal flora, especially anaerobic bacteriodes and clostridia when they are too active in colon. Before operation of colon, something like colostomy, we should have adequate intestinal flora which metabolizes various kinds of bile acids in the inferior digestive tracts. In other words, we have to induce the pathological action of intestinal flora by antibiotics, for instance, Gentamycin and Neomycin, but we should not sterilize all intestinal flora before abdominal surgery, from the viewpoint of detoxication of bile acids on the cecum wall. Therefore, all surgeons have to use adequate peroral antibiotics of aminoglucosides. At that time, simultaneously some celluloses as absorbents of bile acids in foods and non-pathogenous bacteria which metabolize the bile acids in contents of cecum and colon, should be given with such antibiotics, before and sometime after surgical operation of colon. The non-pathogenous bacteria which were mentioned above, would only dissolve the bile acids in colon, but never have any pathogenous function of the formation of micro-abscess and micro-thrombus on sutural woundhealing. At present, such bacilli would be only imaginary bacteria.
近畿大学の論文
1979-09-25

<原著>腸内細菌叢に関する腹部実験外科学

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