<総説>軟部組織に発生の骨外性骨形成性肉腫, 本邦報告例についての検討

概要

論文の詳細を見る
Extraosseous osteogenic sarcoma arising from the various, somatic soft tissues is a rare and malignant tumor. Less than 190 cases in the English literature and only 24 cases including our own case in the Japanese literature have been reported. To establish the diagnosis of this malignancy and to differentiate this tumor from its intraosseous counterpart and other neoplasms having calcification or bone formation, no connection with any skeletal system, an afibrillar, homogeneous and eosinophilic material that is recognizable as malignant osteoid, and frankly sarcomatous stroma should be demonstrated. Careful examination of full skeletal system is necessary to exclude usual osteogenic sarcoma. The multiplicity of sites of occurrence coincides with the proposed etiology for this unusual tumor, that being "the pluri potential property of the proliferating mesenchymal cells to reacquire embryonic properties with resultant osseous metaplasia". Among the Japanese cases (males ; 14,females ; 9,unknown ; 1), only 4 cases (16.7%) have gained postoperative survival of more than three years. Surgical treatment associated with adjuvant chemotherapy or irradiation was effective in three cases of the four. Although this malignancy is very rare, wide excision and adjuvant therapies are necessary to improve the poor prognosis.
近畿大学の論文
1985-09-25