<原著>胸部食道全摘後における消化管ホルモンの変動(第一報) : とくにインスリン, グルカゴン分泌反応について

概要

論文の詳細を見る
The majority of patients of esophageal carcinoma are old of age and have more or less the disturbance of carbohydrate metabolism. The operation of esophageal carcinoma and the change of route of digestive tracts by reconstructive surgery are considered to effect the carbohydrate metabolism especially insulin and glucagon secretion. Since the opening of Kinki University School of Medicine in 1976,the authors have performed the reconstructive surgery by retrosternal gastric replacement after performing total esophagectomy in the chest. This time, we loaded orally 150 ml of trelan G before and 1 month after the esophageal surgery and examined the effect of esophageal reconstruction on carbohydrate metabolism by determining the blood sugar levels, insulin levels and glucagon levels. Consequently, in the group of patients of esophageal carcinoma insulin response was lowered compared with the control group ; however, after the esophageal operation, it was increased in the early phase and was decreased in the late phase. Glucagon secretion was significantly increased in the patients of esophagectomy and this suggests that hyperglucagonemia relates to the disorders of carbohydrate metabolism after the operation of esophageal carcinoma.
近畿大学の論文
1982-03-25