<原著>エールリッヒ腹水癌に対する高圧酸素療法とマイトマイシンC(MMC)の併用効果

概要

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In this report, the combination effect of hyperbaric oxygenation (OHP) and mitomycin-C (MMC) for Ehrlich ascites carcinoma was studied under daily exposure to 100% oxygen at 3 ATA (atmosphere absolute) for 6 days and daily administration of MMC (0.05mg/kg). No life prolongation effect was obtained, when the combined treatment of OHP and MMC was performed within 48 hours after intraperitoneal inoculation of Ehrlich ascites carcinoma cells. But life prolongation effect was obtained in the group treated with OHP and MMC 48-65 hours after intraperitoneal inoculation of Ehrlich ascites carcinoma cells. The histological changes of the tumor cell were examined on the 3rd, 4th, 5th and 6th day after OHP treatment. The tumor cells were taken from the peritoneal cavity and stained by May-Giemsa after each exposure to OHP. The results obtained were as follows, especially in the group treated with OHP and MMC. (1) highly damaged and fused nuclei and cytoplasma. (2) increased number of dead cells. (3) increased number of giant cells.
近畿大学の論文
1976-12-28