<原著>ラット肝切後poly(ADP-ribose)合成酵素活性に及ぼすglucagon-insulin療法の効果

概要

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To elucidate the effect of combined therapy of glucagon and insulin on the hepatectomized remnant liver of rats, postoperative changes of liver nuclear poly(ADP-ribose) polymerase activity were measured. The maximal value of poly(ADP-ribose) polymerase activity without glucagon and insulin was revealed as 354±44 pmol/mg/min at the stage of 5 days after partial hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to peak value of 242±46 pmol/mg/min at the stage of 2 days after the hepatectomy. Regeneration rate in liver weight of the group with glucagon and insulin showed higher values than that of the group without glucagon and insulin in the period from 1 to 5 days and from 7 to 21 days after the hepatectomy. The amounts of DNA showed changes similar to those of poly(ADP-ribose) polymerase activity after the hepatectomy. Thus it is suggested that the combined therapy of glucagon and insulin may act to promote liver regeneration through the changes of poly(ADP-ribose) polymerase activity.
近畿大学の論文
1988-12-25