<SESSION>Development of a Monitoring System for Human Exposure to Tritium : Chromosome Aberrations in Human Lymphocytes Exposed to HTO

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概要

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• Human lymphocytes at G_0 were exposed in vitro to HTO i) to obtain the dose-response relationship between exposure and the dicentric and ring (D+R) frequency, ii) to see the dose-rate effect on the chromosome aberration frequency, iii) to calculate mean value of relative biological effectiveness (RBE) at the dose-range examined, iv) to investigate the enhancing effect of the combined treatment with metabolic inhibitors on the HTO-induced chromosome aberrations, and v) to evaluate the influences of the life-styles of the blood donors on the enhancement to HTO-induced chromosome aberration frequencies by a metabolic inhibitor cytosine arabinoside (ara-C). the does-response curve obtained was shown to be fitted by a power model : Y = 0.205 X^1.29,or a linear quadratic model : Y = 1.5・10^<-3> X + 1.9・10^<-6> X^2,where X is HTO exposure in cGy and Y is the D+R frequency. When lymphocytes were exposed to HTO at 3 different dose rates, it was found that exposure at 0.042 Gy/h produced a 30% smaller number of D+R chromosomes than exposure at 0.5 Gy/h. Mean relative biological effectiveness (RBE) value was estimated to be 1.49 ± 0.21 (Mean ± S.E) within the dose range examined. In cultures exposed to 2-Gy HTO β-rays along with various metabolic inhibitors, a remarkably enhanced ratio of D+R frequencies was observed when cells were combinedly exposed to cytosine arabinoside (ara-C), varying from 2 to 5 among lymphocytes from different blood donors. Caffeine, fluorodeoxyuridine (FUdR) or 3-aminobenzamide (3-AB) also enhanced HTO-induced chromosome aberrations by 20-50% whereas hydroxyurea (HU) and cycloheximide (CHX) appear not to affect the HTO-induced D+R frequency. The bad life-styles of blood donors such as cigarette smoking, drinking alcohol beverages too much, feeling mental stress too much, etc., appeared to significantly influence on the ara-C enhancement effect.

• 核融合科学研究所の論文

著者

• MORIMOTO Kanehisa

  Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine

• OKAYAMA Akira

  Department of Preventive Cardiology, National Cardiovascular Center

• SHIRAKAWA Taro

  Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health

• Okayama Akira

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Shirakawa Taro

  Department Of Health Promotion And Human Behavior Kyoto University

• Shirakawa Taro

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Ogawa Yasutaka

  Department of Hygiene and Preventive Medicine, Osaka University School of Medicine Nakanoshima

• Miura Kunihiko

  Department of Hygiene and Preventive Medicine, Osaka University School of Medicine Nakanoshima

• Miura Kunihiko

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Morimoto Kanehisa

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine

• Ogawa Yasutaka

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

• Morimoto Kanehisa

  Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine Nakanoshima

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