N-Acetyltransferase Polymorphism and Human Cancer Risk
スポンサーリンク
概要
- 論文の詳細を見る
Because of the important role of N-acetyltransferase (NAT) enzymes in both metabolic activation and detoxification of certain precarcinogens, such as homo- and heterocyclic arylamines, extensive research in the past has focused on the relationship between the distribution of different variants of these enzymes and cancer susceptibility. In this context, we examined the relationship between the acetylator type of two NAT isozymes (NAT1 and NAT2) and cancer risk. It was shown that any independent overall association of those diseases with acetylation for either NAT1 or NAT2 is likely to be weak at most. Besides individual genetic profile, differences in the degree of exposure to environmental precarcinogens should also be considered. It was suggested that smoking and red meat intake were associated with both NAT1 and NAT2 genotype in the carcinogenesis. A gene-gene interaction, even linkage between NAT1 and NAT2 may also exist.
- 日本衛生学会の論文
著者
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TAKESHITA Tatsuya
Department of Public Health, Wakayama Medical University
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MORIMOTO Kanehisa
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine
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Takeshita T
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine
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Takeshita Tatsuya
Department Of Social And Environmental Medicine Osaka University Graduate School Of Medicine
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Takeshita Tatsuya
Ntt Opto-electronics Labolatories
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Takeshita Tatsuya
Department Of Social And Environmental Medicine Course Of Social Medicine Osaka University Graduate
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Takeshita Tatsuya
Department Of Social And Environmental Medicine Osaka University Graduate School Of Medicine F1
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Takeshita Tatsuya
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine
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Takeshita T
Department Of Social And Environmental Medicine Course Of Social Medicine Osaka University Graduate
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YANG Xing
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine F1
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Yang Xing
Department Of Social And Environmental Medicine Osaka University Graduate School Of Medicine F1
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Morimoto Kanehisa
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine
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Takeshita Tatsuya
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine
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TAKESHITA Tatsuya
Department of Health Sciences, Yamanashi Medical College
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YANG Xing
Department of Cardiology, the Chinese PLA General Hospital and Military Postgraduate Medical School
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