P300 as a Measure of Cognitive Dysfunction from Occupational and Environmental Insults
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概要
- 論文の詳細を見る
The P300 component of the event-related brain potential (ERP) is a sensitive, noninvasive, and convenient measure of cognitive dysfunction resulting from a variety of etiological agents. Application-orientated research on using the P300 measure as a cognitive probe for a wide range of neurological and psychiatric situations has been expanding rapidly in the last decade. The aim of this paper is to preview issues of application-oriented P300 research in occupational and environment medicine. Firstly, the neurophysiological background of the P300 is outlined. Secondly, the recent findings of P300 abnormalities following various occupational and environmental exposures are overviewed. Thirdly, the empirical issues for application-oriented research such as the potential causes of variability, limitation and difficulty are summarized, with suggestion for controlling them and for future standardization. Finally, it is concluded that P300 assessments demonstrate promising possibility as a sensitive marker for general cognitive dysfunction in occupational and environmental medicine.
- 日本衛生学会の論文
著者
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TAKESHITA Tatsuya
Department of Public Health, Wakayama Medical University
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MORIMOTO Kanehisa
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine
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Takeshita Tatsuya
Department Of Social And Environmental Medicine Osaka University Graduate School Of Medicine
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Takeshita Tatsuya
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine
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Pan Jing
Department Of Social And Environmental Medicine Osaka University Graduate School Of Medicine
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Takeshita T
Department Of Social And Environmental Medicine Course Of Social Medicine Osaka University Graduate
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Morimoto Kanehisa
Department Of Hygiene And Preventive Medicine Osaka University School Of Medicine
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TAKESHITA Tatsuya
Department of Health Sciences, Yamanashi Medical College
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